3-Trifluoromethyl-3-aryldiazirine photolabels with enhanced ambient light stability.
نویسندگان
چکیده
Ambient light stable 3-trifluoromethyl-3-aryldiazirine photolabels are developed via stabilization of the strained three membered diazirine ring by replacing the phenyl ring with electron withdrawing heterocyclic rings. Photolabeling studies reveal that these ambient light stable photolabels are equally efficient in photolabeling target proteins as the traditional 3-trifluoromethyl-3-phenyldiazirine and found to significantly increase the aqueous solubility of the photoaffinity labels.
منابع مشابه
Synthesis and Electroluminescence Properties of 3-(Trifluoromethyl)phenyl-Substituted 9,10-Diarylanthracene Derivatives for Blue Organic Light-Emitting Diodes
Diaryl-substituted anthracene derivatives containing 3-(trifluoromethyl)phenyl) groups, 9,10-diphenyl-2-(3-(trifluoromethyl)phenyl)anthracene (1), 9,10-di([1,1′-biphenyl]-4-yl)-2(3-(trifluoromethyl)phenyl)anthracene (2), and 9,10-di(naphthalen-2-yl)-2-(3-(trifluoromethyl)phenyl) anthracene (3) were synthesized and characterized. The compounds 1–3 possessed high thermal stability and proper fron...
متن کاملIsolation and Reactivity of Trifluoromethyl Iodonium Salts
The strategic incorporation of the trifluoromethyl (CF3) functionality within therapeutic or agrochemical agents is a proven strategy for altering their associated physicochemical properties (e.g., metabolic stability, lipophilicity, and bioavailability). Electrophilic trifluoromethylation has emerged as an important methodology for installing the CF3 moiety onto an array of molecular architect...
متن کاملOzonation of trifluralin particles: an experimental investigation with a vacuum ultraviolet photoionization aerosol time-of-flight mass spectrometer.
The ozonation of trifluralin coated on azelaic acid particles is investigated with a vacuum ultraviolet photoionization aerosol time-of-flight mass spectrometer. The suspended trifluralin particles with the mean diameter of 270nm react with approximately 100ppm ozone in an aerosol reaction chamber under ambient pressure and room temperature (1atm, 298K). The time-of-flight mass spectra of the t...
متن کاملEffect of Salinity, pH, and Temperature on Stability of Gas Condensate in Water Emulsions Using Different Surfactants
Light hydrocarbons in water emulsions are formed in many gas refinery wastewaters, and its stability depends on some parameters such as temperature, pH and salinity. In this study, different surfactants have been used to prepare gas condensates in water emulsion along with four surfactant kinds namely, Span 80, Tween 80, CTAB, SDS and Span 80 and Tween 80 mixture. For this purpose,...
متن کاملNeutral copper(I) dipyrrin complexes and their use as sensitizers in dye-sensitized solar cells.
Heteroleptic neutral copper(I) dipyrrin complexes have been synthesised with the general formula [Cu(4,4'-(R)-6,6'-(CH3)-bipyridine)(dipyrrin)], R = CH3 or CO2Et, and H-dipyrrin is either 1,3,7,9-tetramethyldipyrromethene (HL1), 1,13-diphenyl-6,8-diisoindolemethene (HL2), or 1,13-diphenyl-3,11-di(trifluoromethyl)-6,8-diisoindolemethene (HL3). Improved stability was observed across the series , ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Chemical communications
دوره 52 13 شماره
صفحات -
تاریخ انتشار 2016